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Hello, I'm trying to understand how the processing for the regressors for 1 column vs 3 column differ. Given 1s TRs, I thought that a one column format with say a 1 every 6th TR would produce the same output as a 3 column format with 1 sec durations of height 1 every 6 seconds (see below for an example). When I view the design matrix w/ no convolution, they look similar, but when I convolve w/ the HRF the 3-column format shows substantially greater amplitude changes in predicted signal. What am I missing? Thanks, Nathan 1 0 0 0 0 0 1 0.00000 1.00000 1.00000 6.00000 1.00000 1.00000