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Hey, I usually point to that paper by Mumford, Poline and Poldrack if you have orthogonality related questions: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126255 Hope it helps @+ Remi On 03/01/2018 11:13, Volkmar Glauche wrote: > Hi Aser, > > as Donald already said, the orthogonalized regressors do not share variance. However, there is no reason why only one of them should show an effect in a particular voxel. It all depends on the nature of the dependency between measured signal and modelled design. > > Best regards > > Volkmar