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What statistical issues were you wondering about with this study - you can find a useful synopsis of the results here - just click the data tab. https://mystudies.org/studies.php#studies/df15854b-92ae-429b-9d72-6fe977fe7156/paper James On Jan 4, 2018, at 8:03 PM, yawana tanapat <[log in to unmask]<mailto:[log in to unmask]>> wrote: Can anyone comment on the statistical issues behind the "Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease" in N.Eng J Med 377;12:1119-1131 Sep 21,2017, the appendix which was supposed to explain it all is quite complicated is this a no-inferior trial? if so why use placebo as control? Happy New Year to all Yawana Tanapat MD ________________________________ From: Evidence based health (EBH) <[log in to unmask]<mailto:[log in to unmask]>> on behalf of Juan Gérvas <[log in to unmask]<mailto:[log in to unmask]>> Sent: Wednesday, January 3, 2018 5:06 PM To: [log in to unmask]<mailto:[log in to unmask]> Subject: Re: Happy New Year 2018 A New Year's resolution for all of us: Let's make 2018 the year in which scientific journals said goodbye to statistical significance. We just won't type "statistically significant" in our papers, even if asked by clueless reviewers and editors. Simple way for editors to improve science: If your journal still uses “statistical significance” in 2018, retire your statistical consultan. https://twitter.com/i/moments/864222884000129025<https://nam03.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftwitter.com%2Fi%2Fmoments%2F864222884000129025&data=02%7C01%7C%7Ceef61bf524f84f11f79608d55291bfaf%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C636505708290267943&sdata=FKarVvYIhnm0Yh4pJN0utDkLSjo25WaIGQ%2BIwE3u2Hc%3D&reserved=0> -un saludo juan gérvas @JuanGrvas 2018-01-02 17:36 GMT+01:00 Juan Gérvas <[log in to unmask]<mailto:[log in to unmask]>>: -Anoop, thanks for mention me but it is my pleasure to share what i think are interesting papers -it makes me happy to notice others think the same (from time to time) -for example, this one in English (original) and Spanish (not the best translation but still interesting) Will the fashion for evidence based medicine and technological solutions come to be viewed the same way as brutalist architecture? Yes. The proliferation of rigid yet contradictory clinical guidelines; blunt point-of-care applications; and electronic medical record systems usually described as a hurdle rather than as a tool. http://www.bmj.com/content/359/bmj.j5676<https://nam03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.bmj.com%2Fcontent%2F359%2Fbmj.j5676&data=02%7C01%7C%7Ceef61bf524f84f11f79608d55291bfaf%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C636505708290267943&sdata=2H006hP7J%2BdlZYHo3Zh6upB%2B%2Bkli2%2FTgam8W3yzmafk%3D&reserved=0> La medicina no es una comunidad planificada ni una ciudad de monumentos. Creo que hay sabiduría en el caos de la clínica o el hospital. El poder de la medicina basada en la evidencia es el de una promesa falsa de "solución universal". http://www.nogracias.eu/…/medicina-brutalista-una-reflexio…/<https://nam03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.nogracias.eu%2F2018%2F01%2F01%2Fmedicina-brutalista-una-reflexion-la-arquitectura-los-servicios-salud%2F&data=02%7C01%7C%7Ceef61bf524f84f11f79608d55291bfaf%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C636505708290267943&sdata=rKju4rHfGOCJmzX5B4%2BDORSfCzRalBym%2BOnFUnwhQkM%3D&reserved=0> -un saludo juan gérvas @JuanGrvas 2018-01-02 16:48 GMT+01:00 Vivek Podder <[log in to unmask]<mailto:[log in to unmask]>>: Happy New Year Everyone. Being a medical student, exposure to such forums with excellent evidence-based health discussion helped to gain more insights to it. Thank you. Best, Vivek Podder On Tue, Jan 2, 2018 at 9:34 PM, Homa Keshavarz <[log in to unmask]<mailto:[log in to unmask]>> wrote: Hi Everyone, I also appreciate this forum. All the best wishes to you all. Have a wonder year, Homa -----Original Message----- From: Evidence based health (EBH) [mailto:[log in to unmask]<mailto:[log in to unmask]>] On Behalf Of Anoop Balachandran Sent: Tuesday, January 2, 2018 9:53 AM To: [log in to unmask]<mailto:[log in to unmask]> Subject: Happy New Year 2018 Hi everyone, Just wanted to say thank you to everyone for contributing and sharing your wealth of knowledge and experience in this forum. I am not sure about other folks, but I have gained a lot of knowledge and insight from this forum. I want to thank especially some of the senior members for taking their time out from their busy schedule to answer questions and engage in discussions. I would also appreciate if you write any articles to please post a link in the forum. I know Hilda Bastian writes several excellent articles. Special thanks to Juan for always posting interesting and relevant articles Thank you and happy new year 2018 :) Anoop