Hi Jacob,

Ion-channel and receptor folks have been working on these types of questions... see:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629458/

if you are looking for a model system, perhaps engineer a version of calmodulin that is specific for Na+ rather than Ca++?  Perhaps someone has already done that.

-Conn

Conn Mallett, PhD
Carlsbad, CA
conn.mallett<at>gmail.com
skype: conn.mallett

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Dear Crystallographers,

 

Is anyone aware of a soluble protein which changes large-scale conformation +/- Na+, and is specific for Na+ per se, or at least ignores K+ and Ca++? E.g., Rb+ or Li+ might be okay. Structural info would be a plus, but not a sine qua non.

 

Similarly, what about with K+ or Cl- specificities, but oblivious to similar common ions?

 

All the best,

 

Jacob Keller

 

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Jacob Pearson Keller

Research Scientist / Looger Lab

HHMI Janelia Research Campus

19700 Helix Dr, Ashburn, VA 20147

(571)209-4000 x3159

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