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Hi Jacob, Ion-channel and receptor folks have been working on these types of questions... see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629458/ if you are looking for a model system, perhaps engineer a version of calmodulin that is specific for Na+ rather than Ca++? Perhaps someone has already done that. -Conn Conn Mallett, PhD Carlsbad, CA conn.mallett<at>gmail.com skype: conn.mallett On 9Jan2018 06:42, Keller, Jacob wrote: > > Dear Crystallographers, > > Is anyone aware of a soluble protein which changes large-scale > conformation +/- Na+, and is specific for Na+ per se, or at least > ignores K+ and Ca++? E.g., Rb+ or Li+ might be okay. Structural info > would be a plus, but not a sine qua non. > > Similarly, what about with K+ or Cl- specificities, but oblivious to > similar common ions? > > All the best, > > Jacob Keller > > +++++++++++++++++++++++++++++++++++++++++++++++++ > > Jacob Pearson Keller > > Research Scientist / Looger Lab > > HHMI Janelia Research Campus > > 19700 Helix Dr, Ashburn, VA 20147 > > (571)209-4000 x3159 > > +++++++++++++++++++++++++++++++++++++++++++++++++ > > The content of this email is confidential and intended for the > recipient specified in message only. It is strictly forbidden to share > any part of this message with any third party, without a written > consent of the sender. If you received this message by mistake, please > reply to this message and follow with its deletion, so that we can > ensure such a mistake does not occur in the future. >