P.S. This article might also be helpful: Woo, C. W., Krishnan, A., & Wager, T. D. (2014). Cluster-extent based thresholding in fMRI analyses: pitfalls and recommendations. Neuroimage, 91, 412-419.

On Thu, Dec 7, 2017 at 8:23 AM, Matt T. Richins <[log in to unmask]> wrote:

Dear collective wisdom,

I was given the following request for an imaging paper and I need your advice:

"-For your cluster-based correction for multiple comparisons, an uncorrected P value of .001 is now recommended based on Eklund et al.'s work."

In our analysis, we used a fairly standard threshold of .05 FWE corrected. Is using an uncorrected threshold really advisable now? I've read the Eklund paper but I still don't understand how ignoring the multiple comparisons issue is ok?? Or am I missing something?

Thanks in advance.