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P.S. This article might also be helpful: Woo, C. W., Krishnan, A., & Wager, T. D. (2014). Cluster-extent based thresholding in fMRI analyses: pitfalls and recommendations. *Neuroimage*, *91*, 412-419. On Thu, Dec 7, 2017 at 8:23 AM, Matt T. Richins <[log in to unmask]> wrote: > Dear collective wisdom, > > I was given the following request for an imaging paper and I need your > advice: > > "-For your cluster-based correction for multiple comparisons, an > uncorrected P value of .001 is now recommended based on Eklund et al.'s > work." > > In our analysis, we used a fairly standard threshold of .05 FWE corrected. > Is using an uncorrected threshold really advisable now? I've read the > Eklund paper but I still don't understand how ignoring the multiple > comparisons issue is ok?? Or am I missing something? > > Thanks in advance. >