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Dear EM-ers, It's a pleasure to announce the (hopefully) stable release of relion-2.1.0. The 2.1 release has been in beta-testing since early Summer, and we are grateful to everyone who contributed to its improvement since. A detailed list of bug fixes can be tracked through the github (github.com/3dem/relion). Apart from bug fixes, relion-2.1.0 also contains a bit of new code to deal with local symmetry (see here for details: http://www2.mrc-lmb.cam.ac.uk/relion/index.php/Local_symmetry). We point out that, in order not to destabilise the current code, multi-body refinement (as presented at the NRAMM workshop) is not yet included in this release. We strongly recommend that you update your code (using 'git pull' in your existing installation directory or by cloning again from https://github.com/3dem/relion). Please ask any questions about RELION through this list, and make sure you are using the latest version before reporting problems. Have fun, The RELION development team: Bjorn Forsberg (SciLifeLab) Dari Kimanius (SciLifeLab) Erik Lindahl (SciLifeLab) Takanori Nakane (MRC-LMB) Jasenko Zivanov (MRC-LMB) Shaoda He (MRC-LMB) Sjors Scheres (MRC-LMB) -- Sjors Scheres MRC Laboratory of Molecular Biology Francis Crick Avenue, Cambridge Biomedical Campus Cambridge CB2 0QH, U.K. tel: +44 (0)1223 267061 http://www2.mrc-lmb.cam.ac.uk/groups/scheres