I take it you mean for some semisynthetic approach? One solution that springs to mind would be to get one or both of the azide/alkyne “click” proline derivatives (e.g. http://www.sigmaaldrich.com/catalog/product/aldrich/713643?lang=en&region=GB or http://www.sigmaaldrich.com/catalog/product/aldrich/711977?lang=en&region=GB). Depending on your situation it may be feasible to do a single bulk synthesis then click on a range of different groups after the fact.

Tristan Croll

Research Fellow

Cambridge Institute for Medical Research

University of Cambridge CB2 0XY

On 13 Nov 2017, at 21:15, Jan van Agthoven <[log in to unmask]> wrote:

Sorry for being a bit off-topic, but I’m looking to transform the catalytic properties of a protein I’m working on by adding an aromatic moiety on one of its prolines. However none of the proline derivatives I find commercially are really interesting. Does anyone know what would be the cheapest way to obtain customized proline derivatives? Most companies ask for more then $3000 per compound (about half a mg).