Hi Chirag,

Neither Melodic or the dual regression are by default constrained to gray matter voxels so that could happen. It can be a false positive, or it can mean that there are legitimate signal fluctuations in those regions associated with group differences. The interpretation is up to you.

All the best,

Anderson

On 24 October 2017 at 15:23, Chirag Limbachia <[log in to unmask]> wrote:

FSL Experts,

I read the FAQ for dual regression. It said that finding significant regions outside the given RSN is okay as long as those regions are within the grey matter. I found significant regions in the white matter. My question is, what does it mean if you find significant regions outside the given RSN but within the white matter?

Thank you

Chirag