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Dear Zenhao, i am also currently searching for information and trying to learn how to combine fMRI data and behavioral/questionnaire scores. Hence, i am very interested in any answers on this topic here. My knowledge until now is rather small, but in addition to the other answers i would like to mention a paper from Janaina Mourao-Mirande (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012894/). She gave a talk at the HBM meeting this year and presented a method which (as far as i understood it until now) could be helpful. Here just some quotes from the abstract: "More exploratory approaches, such as Sparse Partial Least Squares (SPLS), may provide insights into the brain's mechanisms by finding relationships between neuroimaging and clinical/demographic data." and "Results: The framework found two statistically significant associative effects between subsets of brain voxels and subsets of the questions/tasks." Maybe that helps. Best, Adam Am 25.09.2017 um 20:56 schrieb Zhenhao Shi: > Dear experts, > > I would like to run a whole-brain multimodal MVPA, using a grey matter > volume map (from VBM) and a functional activation map (from a go/nogo > task) as inputs, and a binary variable (patient vs control) as the > outcome. What I would also like to include in the model are a number > of behavioral predictors such as IQ and reaction times/accuracy on the > go/nogo task. My goal is to find out whether the brain measures and > the behavioral measures TOGETHER are able to classify patients vs > controls. > > I am a new user of PRoNTo, which appears to allow brain predictors > only, but not any behavioral predictors. I wonder if anyone knows how > to construct an integrated BRAIN + BEHAVIORAL prediction model? Should > I switch to another toolbox? > > One possible solution that I could imagine is to create for each > subject a one-dimensional nifti file with each behavioral score > written into one voxel, and enter the VBM map, go/nogo map, and > behavioral "map" as the MVPA inputs. Would this be valid at all? > > Thank you! > > Sincerely, > Zhenhao > > -- > > Zhenhao Shi, Ph.D. > Center for Studies of Addiction, Department of Psychiatry > University of Pennsylvania Perelman School of Medicine > -- Adam Zabicki PhD candidate / Research Assistant / Hum Movement Sci Justus-Liebig-University Giessen Dept. of Psychology and Sport Science Kugelberg 62 35394 Giessen GERMANY eMail: [log in to unmask] Phone: +49 641 9925251 Fax: +49 641 9925229 http://www.uni-giessen.de/nemolab http://www.irtg-brainact.de