Hi all,

I'd like to start a structural MRI longitudinal analysis in my Alzheimer's Disease cohort, studying the atrophy progression. In particular, I'd like to fit a linear mixed effects model using fixed effects of disease duration and a random intercept term for patient.

Most of my subjects have more than 2 timepoints (actually, they have a variable amount of timepoints between 2 and 6), so I don't think SIENA will fit my requirements. Neither FEAT should do that, since it was designed for fMRI.

Any suggestions?

Thanks so much for helping

Fulvio Da Re

PhD student

FTD Center, University of Pennsylvania