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We produced the following short precision study data (Roche hsTnT assay) on a particular patient, having observed a disproportionate drop in results from serial samples. [cid:image001.png@01D3386F.2404B550] Roche concluded, after their own serum fractionation of the sample, that interference was caused by a high molecular weight compound, presumably IgM (and covered by the disclaimer in the method sheet). Regards, Steve Steve Coward Operational Manager, Automation Clinical Biochemistry Belfast Health & Social Care Trust From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of PULLAN, Nicola (ROYAL UNITED HOSPITALS BATH NHS FOUNDATION TRUST) Sent: 28 September 2017 14:19 To: [log in to unmask] Subject: Troponin T /Troponin I discordance Dear Mailbase, Any thoughts on this one... 39 yo female, atypical chest pain, Trop Ts ranging from 150-200 ng/L, extensively investigated by cardiology over last 6 months, no cardiac, muscular or autoimmune process identified. Normal CK NT-pro-BNP: 84 ng/L (<50) Trop I: 4 ng/L (<40) Trop T: 211 ng/L (<14) Has anyone come across/proved assay interference of this kind in Trop T assays? BW Nicola Nicola Pullan PhD FRCPath Consultant Clinical Biochemist Royal United Hospitals Bath NHS Foundation Trust Combe Park, Bath, BA1 3NG Dir Line: 01225 824711 Visit our website at: www.ruh.nhs.uk/pathology<http://www.ruh.nhs.uk/pathology> ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in relation to its contents. To do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland. NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and other accredited email services. For more information and to find out how you can switch, https://portal.nhs.net/help/joiningnhsmail ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ________________________________ This message contains information from Belfast Health And Social Care Trust which may be privileged and confidential. If you believe you are not the intended recipient any disclosure, distribution or use of the contents is prohibited. If you have received this message in error please notify the sender immediately. This email has been scanned for the presence of computer viruses. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/