Hi Nicola,

If you have repeated serial measurements showing discordance, it could be a HAMA or other interferent in the cTnT. I suggest PEG precipitation to exclude a macro-TnT form.

Regards
David

 

Dr. David C. Gaze
Lecturer in Clinical Biochemistry

Course Lead for BSc Biomedical Sciences with Sandwich placement

Department of Biomedical Science
Faculty of Science and Technology
University of Westminster
115 New Cavendish Street
London W1W 6UW
UK

Tel:         +44 (0)20 7911 5000 ext 67314

Direct:   +44 (0)20 3506 7314
E mail:    [log in to unmask]

 

From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of PULLAN, Nicola (ROYAL UNITED HOSPITALS BATH NHS FOUNDATION TRUST)
Sent: 28 September 2017 14:19
To: [log in to unmask]
Subject: Troponin T /Troponin I discordance

 

Dear Mailbase,

 

Any thoughts on this one…

 

39 yo female, atypical chest pain, Trop Ts ranging from 150-200 ng/L, extensively investigated by cardiology over last 6 months, no cardiac, muscular or autoimmune process identified.

 

Normal CK

NT-pro-BNP: 84 ng/L (<50)

Trop I: 4 ng/L (<40)

Trop T: 211 ng/L (<14)

 

Has anyone come across/proved assay interference of this kind in Trop T assays?

 

BW

Nicola

Nicola Pullan PhD FRCPath
Consultant Clinical Biochemist
Royal United Hospitals Bath NHS Foundation Trust
Combe Park, Bath, BA1 3NG

Dir Line: 01225 824711
Visit our website at: www.ruh.nhs.uk/pathology

 

 

 



********************************************************************************************************************

This message may contain confidential information. If you are not the intended recipient please inform the
sender that you have received the message in error before deleting it.
Please do not disclose, copy or distribute information in this e-mail or take any action in relation to its contents. To do so is strictly prohibited and may be unlawful. Thank you for your co-operation.

NHSmail is the secure email and directory service available for all NHS staff in England and Scotland. NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and other accredited email services.

For more information and to find out how you can switch, https://portal.nhs.net/help/joiningnhsmail

------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/

The University of Westminster is a charity and a company limited by guarantee. Registration number: 977818 England. Registered Office: 309 Regent Street, London W1B 2UW.

This message and its attachments are private and confidential. If you have received this message in error, please notify the sender and remove it and its attachments from your system.

------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/