Dear Matteo,

yes, BIANCA requires some images where the WMH are labelled, to learn how to classify them in the rest of the subjects.

You will need to prepare some binary images of WMH (1 inside the lesions, 0 outside) from your data (usually FLAIR is used as the WMH are better identifiable)

I would suggest 10 subjects to start with (in our experience it works better if you use the ones with higher WMH load) and then see if you are happy with the results or you need to add more.

Hope it helps,

Ludovica

— 

Ludovica Griffanti, PhD
Analysis Postdoctoral Research Assistant
Wellcome Centre for Integrative Neuroimaging (WIN)

Oxford Centre for Functional MRI of the Brain (FMRIB)
Nuffield Department of Clinical Neurosciences, University of Oxford
John Radcliffe Hospital
Oxford, OX3 9DU, UK
email: ludovica.griffanti@ndcn.ox.ac.uk

On 27 Jul 2017, at 7:53 pm, Matteo Respino <[log in to unmask]> wrote:

Hi everyone,

it's the first time I try Bianca and I've been reading the provided user guide.
I do not get the "training dataset preparation" step: am I supposed to manually mask the WMH within some of my FLAIR images?
If yes, how many sbj are required for having a training set?

Thanks in advance
Best
Matteo