Dear Mark, Thank you so much for your advise. As each subject has 2 time scans, should I add Exchange Block (EB) into model? I tried with EB and this made the design rank deficient. Many thanks, Best regard, Kim TD On Mon, 28 Aug 2017 14:18:56 +0000, Mark Jenkinson <[log in to unmask]> wrote: >Hi, > >Yes, you can add a covariate to this model. Just make sure that: >1 - it is demeaned >2 - it is not the same as one of the factors or a combination of them (as this would make the design rank deficient) > >If your confound varies with subject then the second condition should be met, in which case just make sure that you demean the values before entering them into the EV. > >All the best, > Mark > > >> On 28 Aug 2017, at 10:58, Kim TRAN <[log in to unmask]> wrote: >> >> Dear FSL expert, >> >> I want to perform an ANOVA model for 2-groups, 2-levels per subject (2-way Mixed Effect ANOVA) following fslwiki GLM. Otherwise, I also doubt about some confounding factors, could I add them to model as covariate? I really appreciate any advice you can provide. >> >> Best regard, >> >> Kim TD