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Dear Mark,

Thank you so much for your advise. As each subject has 2 time scans, should I add Exchange Block (EB) into model? I tried with EB and this made the design rank deficient. 

Many thanks,

Best regard,

Kim TD

On Mon, 28 Aug 2017 14:18:56 +0000, Mark Jenkinson <[log in to unmask]> wrote:

>Hi,
>
>Yes, you can add a covariate to this model.  Just make sure that:
>1 - it is demeaned
>2 - it is not the same as one of the factors or a combination of them (as this would make the design rank deficient)
>
>If your confound varies with subject then the second condition should be met, in which case just make sure that you demean the values before entering them into the EV.
>
>All the best,
>	Mark
>
>
>> On 28 Aug 2017, at 10:58, Kim TRAN <[log in to unmask]> wrote:
>> 
>> Dear FSL expert,
>> 
>> I want to perform an ANOVA model for 2-groups, 2-levels per subject (2-way Mixed Effect ANOVA) following fslwiki GLM. Otherwise, I also doubt about some confounding factors, could I add them to model as covariate? I really appreciate any advice you can provide.
>> 
>> Best regard,
>> 
>> Kim TD