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Hi Yes sure you can use randomise to compare different spatial histograms. But make sure you divide all voxels of fdt_paths by the value stored in “waytotal”. Cheers Saad > On 5 Aug 2017, at 21:22, Francesco Sammartino <[log in to unmask]> wrote: > > Hi > I want to fit a linear model to each voxels of individual seed to all brain connectivity maps (fdt_paths) . I have the same subject analyzed with different seed sizes (it is a simulation study where we are looking at the different white matter connectivity associated with a series of different electrical stimulation parameters). > Which would be the best model to apply? Linear model with multiple comparison correction through randomise > Thanks a lot > Francesco Sammartino > >