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Hi Mark, Thank you so much for the reply. I was using the GUI to direct to the folder called **.bedpostX which was created by the running BEDPOSTX and it is parallel to the input directory I indicated. Then I activate "main structural image" and select the BETed T1 volume and then hit GO. Then the error message appear. And I found that I have nodif_brain_mask.nii.gz in the .bedpost folder already, but not the nodif_brain.nii.gz file. So which file does registration require? Do I manually put this b0 file in the folder? Thanks. Miao 2017-08-28 7:18 GMT-07:00 Mark Jenkinson <[log in to unmask]>: > Hi, > > This indicates that it cannot find the image: mydirectory/nodif_brain > It probably means that you have specified the image incorrectly in the GUI. > Did you use the GUI-based file browser to select the file? > That is generally the safest way to make sure that the image file exists > and that you have the full path to the file specified correctly. > > All the best, > Mark > > > On 27 Aug 2017, at 07:08, Miao Wei <[log in to unmask]> wrote: > > > > Hi FSL community, > > I did all preprocessing and finished BEDPOSTX now and want to do > registration in FDT. But it give me the following error message. Can anyone > help me with how to get through this? > > "Error: image Exception: #22 Error: could not open image > mydirectory/nodif_brain terminate called after throwing an instance of > ''RBD_COMMON:: Base Exception" > -- Miao Wei