Dear Sadjad
That sounds like a very interesting analysis. To clarify - what's your objective for this analysis? Is it to validate DCM? Or to ask something specific about haemoynamics? I am wondering if there's a particular reason you went for DCM for fMRI, rather than a biophysical model which explicitly models firing rates i.e. the canonical microcircuit (CMC) model.

Best
Peter

-----Original Message-----
From: Sadjad Sadeghi [mailto:[log in to unmask]COM]
Sent: 06 July 2017 16:34
To: [log in to unmask]; Zeidman, Peter <[log in to unmask]>
Subject: Re: VOI Time series adjustment

Dear Peter,

Thanks a lot for your reply. Yes I am working on DCM for fMRI and I have found the best model for effective connectivity between 3 regions, then I have simulated the same connectivity model for a spiking network model which originally was designed for the prefrontal cortex. Each region consists of 1000 neurons and it gives the spiking times of each neuron, then I converted the spiking times of the neurons to have the firing rate vs. the simulation time (in order to have the same output as predicted data from DCM). For the input to this simulated network, I can only determine the frequency of it, that is why I am also looking for the frequency to enter the same strength of input as my experimental tasks! (as at the moment the timeseries in DCM.U.u has only the value of 1 and 0 ). Then I need to match this time series with time series from DCM analysis to implement experimental tasks within spiking network model afterward. I hope this was enough and looking forward to your more feedbacks about my questions.

Best wishes,
Sadjad Sadeghi