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I believe the output is 1-p so a threshold of 0.05 means p < 0.95 .Which will indeed include a lot of voxels, but is not meaningful. Threshold of 0.95,1 is what you should use. Which means you don't have any significant difference. However, 9 is a rather small group size. Best wishes Michael ________________________________ From: FSL - FMRIB's Software Library <[log in to unmask]> on behalf of Ramesh Babu <[log in to unmask]> Sent: 09 July 2017 13:45 To: [log in to unmask] Subject: [FSL] Interpretating dual regression output Dear Experts, I need your help to produce final result of dual regression. I have two groups control (A) and patient (B), 9 participants in each group. I did dual regression analysis as mentioned in the ICA practical documents. I did not find any activity when comparing both the groups with threshold min 0.95 and max 1. But when I change it to .05 and 1 I found activities in both the groups and also out side the brain for A<B. How to interpret the result? Please see the link and give your suggestions. https://drive.google.com/open?id=0B35WvETy7qd9RF83OEJxZ3NrMlU https://drive.google.com/open?id=0B35WvETy7qd9VHhYY043X1RFcUE [https://lh3.googleusercontent.com/ogGfyllcmN81SnF0lRtgGoqaUPPXXuLrWaSM02ZoH46_wzoeXS_0WA=w1200-h630-p]<https://drive.google.com/open?id=0B35WvETy7qd9VHhYY043X1RFcUE> A<B.png<https://drive.google.com/open?id=0B35WvETy7qd9VHhYY043X1RFcUE> drive.google.com Thanks RB