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Dear ccp4-ers, I have a data set at 2.8 A. There is clear *continuous* density for a ligand + residue. I used the LINK record to connect the S-gamma-atom from Cys to C1-atom of ligand OCA. My biochemistry collaborator says that CB-SG-C1-O1 should be approximately planar. However, during refinement with REFMAC5, the connecting region does lose planarity. The ligand and residue does indeed stay properly inside the density. I assume this is due to the low(er) resolution. Should I fix the planarity or should I leave it to the refinement? Thank you all, Markus