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Dear Christian, Thank you for your feedback. The increase sulcal depth, if not due to atrophy of white matter, couldn't it be caused by partial volume effect in case of high atrophy that leads to decreased gradient between white and gray matter ? How could I verify this if possible ? I have noticed also that sulcal depth seems to be less sensitive than cortical thickness. But in case of thorough atrophy on whole brain it seemed to be more specific. Considering fractal dimension, that appeared to be more used in psychiatry than neurodegeneration, how would you interpret decrease of this parameter in patient with AD ? Finally, I would like to ask you how could I find in the package where surface parameters are coded ? Thank you for your help ! Best regards, Matthieu Le 24 juin 2017 9:02 AM, "Christian Gaser" <[log in to unmask]> a écrit : Dear Matthieu, my expectation about changes in sulcal depth for a large atrophy would be also an increased sulcal depth du to the loss of gray and also to some extent white matter. However, I am not that satiesfied with the sulcal depth measure because it does not seem to be such a sensitive measure. Furthermore, sulcal depth seems to be influenced by current atropy but also by folding changes (such as gyrifiction). The latter would rather point to an neurodevelopmental effects. Best, Christian On Fri, 23 Jun 2017 13:44:49 +0000, Matthieu Vanhoutte < [log in to unmask]> wrote: >Dear Christian, > >I have used CAT12 to analyze surface features on patients versus controls. > >Surprisingly, I have found in Alzheimer patients a higher sulcal depth in >cingulate gyrus/sulcus compared to controls, whereas studies often show >that sulcal depth diminish in patients. > >1) Would you have an explanation on this ? >2) Considering sulcal depth measure, is there a meaning to consider >significant patterns on gyri ? > >Thank you for the feedback. > >Best regards, >Matthieu >