Hi, It is fine to continue with this data, as no information has been lost. The output of almost all processing steps with use FLOAT32 for storage, so this is totally normal. All the best, Mark On 2 Jun 2017, at 05:55, Ramesh Babu <[log in to unmask]<mailto:[log in to unmask]>> wrote: Dear Experts, To reorient my data to standard space, I used fslreorient2std grp110_t1.nii grp110_t1.nii.gz After reorientation data type is changed, which I have highlighted in the output of fslinfo. And data size also doubled (22.9 to 45.9 MB). Can I continue with this data type or should I change it? If I have to change data type, how to change the data type? $ fslinfo grp110_t1.nii data_type INT16 dim1 256 dim2 256 dim3 175 dim4 1 datatype 4 pixdim1 1.000000 pixdim2 1.000000 pixdim3 0.999996 pixdim4 0.007554 cal_max 0.0000 cal_min 0.0000 file_type NIFTI-1+ $ fslinfo grp110_t1.nii data_type FLOAT32 dim1 175 dim2 256 dim3 256 dim4 1 datatype 16 pixdim1 0.999996 pixdim2 1.000000 pixdim3 1.000000 pixdim4 0.007554 cal_max 0.0000 cal_min 0.0000 file_type NIFTI-1+ Thanks Ramesh