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Hi Michiko, Is it the case that one of the two patient groups is more similar to the controls than the other group? If yes, then would need a separate template, otherwise, can use the same. If really unsure, make a new one for this side analysis (patients only). All the best, Anderson On 12 June 2017 at 06:31, SUBSCRIBE MRICRO Michiko <[log in to unmask]> wrote: > Dear Anderson, > > Thanks very much for your replies and for clarifying. > > I think it's not a problem to use the same template for all models if the > template uses all subjects from all groups. The problem that could happen > in group comparisons is that the template could favour one of the groups, > but in your analysis, either all groups will be in the model (so, a > template using all groups won't be biased), or the other models will not > make group comparisons. So, in my view, it's ok to use the same template > using subjects from all groups for all the proposed analyses. > > >>> You mentioned "the other models will not make group comparisons", > however the purpose of the 2nd model is to make group comparisons between > the first and second patient groups with the inclusion of the > patient-specific variables. Is it then still fine to use the group-based > registered template (that includes the healthy controls) in this case? > > Thanks very much, > Michiko > >