My guess is that it is the usual problem of not having good starting estimates. Before you do anything with your images, run CheckReg with a selection of the images and one of the MNI-space images released with SPM. If the images are poorly aligned, then things will fail. Orientations should be within about 15-20 degrees, and the positioning should be within 3-4 cm. Best regards, -John On 3 May 2017 at 02:48, Megan Finnegan <[log in to unmask]> wrote: > Hello SPM Experts, > > I'm trying to run a segmentation in SPM12 on a structural and am getting > some strange results. I tried running a grey and white matter segmentation > via the batch editor. This is my first time working with segmentation, so > I've just used the default settings. However the segmentation appears to > fail. I also tried doing the segmentation in the conn toolbox and it seems > to come out as expected. > > I've attached a screen shot of the segmenations from both the SPM12 > batching GUI (left set of images) and the conn toolbox (right set of > images). What could be causing these results? > > Thanks! > > ~Meg > >