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Dear Guillaume, I want to use the LST from the SPM toolbox, I have selecting the Lesion Segmentation Algorithm (LPA) and I have selecting my FLAIR image... But when I run it, I get this error : Running job #8 ------------------------------------------------------------------------ Running 'LST: Lesion segmentation (LPA)' ------------------------------------------------------------------------ This is LST www.statistical-modeling.de/lst.html Algorithm: Lesion prediction algorithm (LPA) If anything goes wrong: LST_log_20170427_131110.txt Number of jobs to process: 1 Coregister to reference images: no Working on job 1 out of 1 (100%) Warning: Escape sequence 'U' is not valid. See 'help sprintf' for valid escape sequences. > In ps_LST_lpa at 188 In matlabbatch\private\cfg_run_cm at 29 In cfg_util>local_runcj at 1510 In cfg_util at 830 In cfg_ui>MenuFileRun_Callback at 1186 In gui_mainfcn at 96 In cfg_ui at 53 Current directory C:Warning: Escape sequence 'U' is not valid. See 'help sprintf' for valid escape sequences. > In ps_LST_lpa at 190 In matlabbatch\private\cfg_run_cm at 29 In cfg_util>local_runcj at 1510 In cfg_util at 830 In cfg_ui>MenuFileRun_Callback at 1186 In gui_mainfcn at 96 In cfg_ui at 53 Preprocessing of t2_tirm_tra_dark_fluid_320.nii Failed 'LST: Lesion segmentation (LPA)' Index exceeds matrix dimensions. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\Seg\spm_maff8.m" (v4152), function "M2P" at line 249. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\Seg\spm_maff8.m" (v4152), function "affreg" at line 111. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\Seg\spm_maff8.m" (v4152), function "spm_maff8" at line 27. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\LST\ps_LST_spm_preproc_run.m" (v6217), function "run_job" at line 105. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\LST\ps_LST_spm_preproc_run.m" (v6217), function "ps_LST_spm_preproc_run" at line 42. In file "C:\Users\asus\Desktop\SPM8\spm8\toolbox\LST\ps_LST_lpa.m" (???), function "ps_LST_lpa" at line 249. The following modules did not run: Failed: LST: Lesion segmentation (LPA) Could you help me correcting this error please !! Best!