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Hi Gina, Sounds something to be expected: there is a global effect. Once that is taken into account, regional effects disappear or become much attenuated (could even have reversed). This could be the case with either FS or FIRST. Not sure what the issue it: it doesn't seem to be wrong, and not surprising either. All the best, Anderson On 10 April 2017 at 08:20, Gina Rippon <[log in to unmask]> wrote: > This is possibly a naïve question but I would like advice on the > comparability of total brain volume correction techniques in different > software packages. I am commenting on a paper that uses Freesurfer for > cortical parcellation and FIRST for subcortical segmentation. Initial > observations of sex differences in cortical and subcortical volumes (all > M>F) are reported to be differentially affected by subsequent brain volume > corrections - with respect to cortical zones, M>F differences remain > (though effect size attenuated); with respect to subcortical structures, > virtually all sex differences disappeared. Any comment/advice gratefully > received. >