Print

Print


Does the Hauptman-Woodward Medical Research Institute have any sample 
data-sets, so we can see what the results look like?



On 4/14/2017 8:58 AM, Edward Snell wrote:
>
> Dear Elizabeth,
>
>
> The High-Throughput Crystallization Screening Center and the 
> Hauptman-Woodward Medical Research Institute has been operating for 
> over a decade with considerable success. There are comprehensive 
> details at http://getacrystal.org but basically your samples are 
> screened against a large range of commercially available conditions 
> plus some more unique ones. Video microscope images are provided over 
> a period of six weeks or longer by request and the imaging also 
> includes SONICC (detecting very tiny crystals or crystals in 
> precipitate) and UV-TPEF to ensure the sample is protein. There are a 
> large range of analysis tools that can be used on the data. Much of 
> the information is provided on the link above. Success rates are 
> pretty high and many entries in the PDB have had their initial crystal 
> hits there.
>
>
> I hope this helps, the center does not advertise much but works with a 
> lot of laboratories.
>
>
> Cheers,
>
>
> Eddie.
>
>
> Edward Snell Ph.D.
>
> President and CEO Hauptman-Woodward Medical Research Institute
>
> Assistant Prof. Department of Structural Biology, University at Buffalo
>
> 700 Ellicott Street, Buffalo, NY 14203-1102
>
> hwi.buffalo.edu <http://hwi.buffalo.edu/>
>
> Phone:     (716) 898 8631         Fax: (716) 898 8660
>
> Skype: eddie.snell                 Email: [log in to unmask] 
> <mailto:[log in to unmask]>
>
> Heisenberg was probably here!
>
>
>
> ------------------------------------------------------------------------
> *From:* CCP4 bulletin board <[log in to unmask]> on behalf of 
> Elizabeth Diaz <[log in to unmask]>
> *Sent:* Friday, April 14, 2017 9:06 AM
> *To:* [log in to unmask]
> *Subject:* [ccp4bb] Recommendations for Robotic Crystal Screening 
> Services
> All,
>
> I am currently attempting to crystallize a peptide/protein complex and 
> am wanting to know about robotic screening services that you would 
> recommend. We have done some in house conditions with little luck, and 
> want to broaden our search, but that would require going externally 
> for screening. Do you have any recommendations for robotic crystal 
> screening services, preferably in the United States?
>
> Thank you so much,
>
> Elizabeth Diaz
> University of Delaware