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University of Edinburgh School of Mathematics and BioSS Date: Friday 21st April, 15:10 Location: JCMB 5323 Speaker: Professor Elizabeth Thompson, University of Washington Title: Models and methods for the estimation of the shared descent of genome Abstract: Genome is copied from parents to offspring, leading to genetic similarities among related individuals, since DNA copies that descend from a single piece of DNA in a recent common ancestor have high probability of being of the same type. Conversely, genetic similarities among current individuals can be used to estimate the parts of their genome that are shared by descent. With modern genetic marker (SNP) data, we can estimate proportions of genome shared and numerous pairwise statistical measures of this “realized relatedness” have been proposed. Here we emphasize two important often disregarded aspects: dependence across the genome and dependence among individuals. First genome descends and functions in segments; models and methods for the detection of shared segments of genome can greatly increase accuracy. Second genome descends jointly to current members of a population: pairwise analyses lose information. I will present some recent approaches to estimation of the joint patterns of shared genome segments among multiple individuals. This seminar is a part of Maxwell Institute seminar series. You may leave the list at any time by sending the command SIGNOFF allstat to [log in to unmask], leaving the subject line blank.