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As usual, my best guess is that the positioning information in the image header is corrupt. I'd suggest trying a CheckReg between your image and the MNI-space templates released with SPM. If the images are not within about 4cm and 15 degrees of each other, you should adjust the positioning information in the image header. Best regards, -John On 22 March 2017 at 16:57, David Hofmann <[log in to unmask]> wrote: > Hi, > > I get the following error during segmentation and I'm not sure what the > problem is. It seems the input to the SVD consists only of NaNs: > > >> >> SPM12: spm_preproc_run (v6365) 23:42:13 - 21/03/2017 >> ======================================================================== >> Segment X:\sub87568\mprage_skullstripped.nii >> Warning: Matrix is singular to working precision. >> > In spm_get_closest_affine at 61 >> In spm_preproc_write8 at 337 >> In spm_preproc_run>run_job at 146 >> In spm_preproc_run at 41 >> In spm_cfg_preproc8>spm_local_preproc_run at 418 >> In matlabbatch\private\cfg_run_cm at 29 >> In cfg_util>local_runcj at 1688 >> In cfg_util at 959 >> In spm_jobman>fill_run_job at 458 >> In spm_jobman at 247 >> > > >> Failed 'Segment' >> Error using svd >> Input to SVD must not contain NaN or Inf. >> In file "..\spm12\spm_get_closest_affine.m" (v6137), function >> "spm_get_closest_affine" at line 68. >> In file "\spm12\spm_preproc_write8.m" (v6881), function >> "spm_preproc_write8" at line 337. >> In file "\spm12\spm_preproc_run.m" (v6365), function "run_job" at line >> 146. >> In file "\spm12\spm_preproc_run.m" (v6365), function "spm_preproc_run" at >> line 41. >> In file "\spm12\spm12\config\spm_cfg_preproc8.m" (v6798), function >> "spm_local_preproc_run" at line 418. >> > > Additionally, there is a warning during coregistration which might be > related to this: > > >> SPM12: spm_coreg (v6435) 23:29:07 - 21/03/2017 >> ======================================================================== >> Warning: Too many optimisation iterations >> > In spm_powell at 46 >> In spm_coreg at 149 >> In spm_run_coreg at 22 >> In matlabbatch\private\cfg_run_cm at 29 >> In cfg_util>local_runcj at 1688 >> In cfg_util at 959 >> In spm_jobman>fill_run_job at 458 >> In spm_jobman at 247 > > > Does anybody have an idea what went wrong and how to fix it? > > greetings > > David > >