UK NEQAS for Steroid Hormones will be able to access the following:

 

https://results.ukneqas.org.uk/output/QEHSTER/Prog_Rainbow_A1_Instr_2015.pdf

 

Regards

 

Aimee

 

Aimee McGrory
EQA Support Scientist - NEQAS

 

 

 

Angela

 

We quote  the values stated in the NICE guidelines, see extract below

 

Derek

 

 

 

 

 

 

Just to clarify, we do use the Siemens Centaur method for Progesterone in Leicester

 

 

 

Hi Angela,

 

This is my personal view:

 

In a normal menstrual cycle (28Day), progesterone is produced by the corpus luteum after ovulation has occurred at mid-cycle (D14) and continue to rise to a peak at D21. Therefore I would argue that ovulation occurs even if D21 progestrone is as low as 10 nmol/L, however this would suggest unhealthy corpus luteum that is unable to sustain healthy decidual endometrial growth in order for the fertilised ovum to implant.

 

In a regular 28D cycle, ovulation should occur in every cycle and D21 progesterone  is only an index of corpus luteal health and not an index of ovulation. The higher D21 progesterone the more likely that healthy decidual reaction occurs ready for implantation of fertilised ovum.

 

So D21 progesterone of 10 – 20 nmol/L means that ovulation has happened but corpus luteal function is inadequate to support decidual reaction so implantation of a fertilised ovum is less likely to happen.

Day21 progesterone of 21 – 28 nmol/L also means that ovulation has happened but luteal function is sub-optimal but could support decidual reaction and therefore offer some chance for implantation.

Day 21 progesterone of >29  nmol/L, luteal function is healthy and there is a higher chance of successful implantation of a fertilised ovum.

Day 21 <10 nmol/L, there will be minimal if any decidual reaction, so no chance of implantation even if ovulation has occurred..

 

Therefore we should not be linking D21 progesterone to ovulation but instead we should link it to corpus luteal function.

 

Regards

 

Mohammad

 

 

 

Dear Mailbase

 

We have been contacted by our Gynaecologists suggesting that we lower our current cut-offs for day 21 progesterone. We currently report the following cut-offs:

>30  nmol/L  it's probably Ovulatory

20-30 nmol/L  it's Equivocal      

<20  nmol/L  it's probably Non Ovulatory

      

Based on audit work the Gynaecologists have suggested the following cut-offs:

>20 nmol/L probably ovulatory
10-20 nmol/L equivocal
< than 10: probably non-ovulatory

 

What do other labs use?

 

Kind regards

 

Dr Angela Burns née Kinnell

Senior Clinical Scientist

The Department of Chemical Pathology and Metabolic Medicine

Level 4, Sandringham Building

Leicester Royal Infirmary

LE1 5WW

 

 

 

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