This is to be expected. The deconvolution process of different seeds (A vs B) leads to different significance in the results.

Best Regards, 

Donald McLaren, PhD

On Mon, Feb 20, 2017 at 10:58 AM, Dr. Delin Sun <[log in to unmask]> wrote:

Dear Dr. McClaran and gPPI experts,

May I know whether the gPPIs from a seed region A to target area B should be the same as the gPPIs from B to A? I found in my data that gPPIs of A-->B are little different from those of B-->A. Any reply is appreciated.

Bests,
Delin Sun