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Hi,

It isn't possible on the basis of just these numbers to determine which is the best result.
It is true that the asymmetry that you are seeing here is unusually large, and that this might well indicate problems with the segmentation.  However, the only way to really know is to look at your images and determine, by examining them, where the hippocampal segmentations are good or not.

So have a good look at the images and then let us know if you are still not sure.

All the best,
Mark



On 4 Feb 2017, at 04:16, Ramesh Babu <[log in to unmask]> wrote:

Dear Expert,

We have scanned three subjects with different T1 sequences and performed sub cortical volume analysis using first_run_all script & fslstats. 
Given below is the details of hippocampal volume for different T1 sequences.

Subject-1
fslinfo P1_T1.nii.gz
data_type   FLOAT32    175x256x256    datatype 16    0.9x1x1
cal_max     0.0000         cal_min   0.0000     file_type      NIFTI-1+

Hippocampal volume (output from terminal): Lt 3702    3701.971756       Rt 4090    4089.968796 
In this case number of voxels and volumes are similar.

Subject-2;  fslinfo P5_T1.nii.gz    
data_type  FLOAT32    301x240x240     datatype 16   0.599x1.04x1.04
cal_max    0.0000    cal_min    0.0000    file_type      NIFTI-1+

Hipocampal volume: Lt 4583  2983.678203      Rt 3249  2115.201938
In this case number of voxels and volumes are different.


Subject-3a
fslinfo rb1.nii.gz 
data_type   INT16    dim   175x256x256     datatype  4   pixdim     0.99x1x1
cal_max     0.0000   cal_min    0.0000    file_type      NIFTI-1+

Hippocampal volume: Lt 4732 4731.963898        Rt 4537 4536.965385  
In this case unmber of voxels and volumes are similar
.

Subject-3b;
fslinfo rb2x2.nii.gz      
data_type  FLOAT32    dim   176x128x128     datatype  16    pixdim   0.99x2x2
cal_max    0.0000      cal_min   0.0000     file_type      NIFTI-1+

Hipocamal volume: Lt 755 3019.953918      Rt 862 3447.947388
In this case number of voxels and volumes are different.

Could expert explain me which sequence is the best for such kind of analysis particularly voxel based morphometric analysis?


Thanks in advance
Ramesh