Hi Isik,

Thanks for sending in .ods format. For within-subject effects, given that age doesn't change between the three conditions, it doesn't have to be included in the model. The subject-specific EVs already take care of anything that is subject-specific, such as age. So, age can be omitted.

Unless in the scenario in which age (or some other variable that is constant within subject) could be affect the differences between the conditions, that is, an interaction age by condition, which is what you'd like to test. Then it's different.

Please see at this link a design for this: https://dl.dropboxusercontent.com/u/2785709/outbox/mailinglist/design_isik.ods

There are 4 different designs inside:

- design1: within-subject effects, no age

- design2: between-subject effects, no age

- design3: within-subject effects, with age and interactions

- design4: between-subject effects, with age and interactions

Answering the earlier questions:

1) The interactions make demeaning a bit confusing. It's needed for some, not needed for others, but where not needed, it doesn't affect. So, to make it simpler, do the mean centering.

2) You can if you want. Just test the contrast [1 1 0 0 0 ... ]

3) Looks correct: should be one EB per subject for this design.

For the call to PALM: need to add "-t design.con". Also, I recommend using -logp, as the figures later will look more informative, with better contrast. Significant values are those above -log10(0.05) = 1.3.

Optionally you can accelerate the run with "-approx tail -n 500 -nouncorrected".

Hope this helps!

All the best,

Anderson

On 15 February 2017 at 14:49, Isik Karahanoglu <[log in to unmask]> wrote:

Oh sorry about that, I attach the .ods.