Hi Nancy,The value of the COPE is neither t or z. It is the slope of the regression line, i.e., the "beta". The meaning depend on the type of data. For FMRI, this value isn't usually interpretable directly but it can be converted to a percentage signal change.All the best,AndersonOn 14 February 2017 at 17:01, Nancy Li <[log in to unmask]> wrote:Hello experts,I want to run ROI in the Matlab. After I run the Feat in FSL. I got the cope image of every subject. And I fslmerge all the images in one 4D image. Then I gunzip the merged 4D image in the matlab and try to induce the value of ROI in every subject. (1)Does the process look normal? (2) the value of ROI through this way is Z value or t value? Thank you so much. Looking forward to your instruction.BestNancy