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Dear Mohammed, If you click on the "Hemodynamics" button when looking at SPM results, it will estimate the parameters of a hemodynamic model from the first eigenvariate time-series within in a ROI. Best regards, Guillaume. On 20/01/17 15:59, Boureghda Mohammed wrote: > Is the signal extracted by the eigenvariate (SPM12) is the real BOLD signal that can be used as a real observations to identify one of the paradigm that models the neuronal activity of the brain like the BALLOON HEMODYNAMIC MODEL (Friston 2000)? > -- Guillaume Flandin, PhD Wellcome Trust Centre for Neuroimaging University College London 12 Queen Square London WC1N 3BG