Hello all, I am stuck on making the model for a 2x2 repeated measure ANOVA with a covariate. It will be great if someone could help me with it! Our study design is: two groups of people, go through either Purple or Control intervention (between-subject); everyone has two scans, pre and post intervention (within-subject). Now, we have seen that subjects' rating scores are negatively correlated with insula activation in pre-post contrast in the Purple group. Meaning if they rate higher on grating, they would experience a smaller decrease in insula. Now, we want to compare this effect between Purple and Control group. The score is only collected once. Assuming we have 4 people, 2 purple 2 control, and they have scores as purple1=5, purple2=2, control1=4, control2=3 ev1 ev2 ev3 ev4 ev5 ev6 ev7 P1 pre 1 1 5 P2 pre 1 1 2 P1 post -1 1 -5 P2 post -1 1 -2 C1 pre 1 1 -4 C2 pre 1 1 -3 C1 post -1 1 4 C2 post -1 1 3 and contrast be ev7=1? or should I have ev7 as 5, 2, -5, -2, 4, 3, -4, -3 and have the contrast as ev1=1, ev2=-1, ev7=1? Sincerely, Ting