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Hi

It looks like you've got the Windows environment variable "MOSDIR" set to "E:\" when running CCP4i - I have no idea how that would happen; it's normally set to something like C:\MOSDIR. If you haven't got an E:\ drive that would be the root of your problem...

Have a look in the list of Windows environment variables - I haven't done this since my XP days, but you should be able to find it by looking at the advanced system settings, were there should be a button to give you a list of environment variables.

Since I'm not familiar with ccp4i on W7 I can't say much more. 

On 19 Jan 2017, at 03:40, Jiang Xu wrote:

Hi, Mr/Ms,
   I am a user of CCP4i. I recently discovered that imosflm cannot be used on my win7. the error message is shown below.
   <image.png>
  However, when I go to 'bin' folder and double click the imosflm.bat, the program can be start up successfully. I don't know what's the problem. 
    Thank you!
Best!
Jiang Xu
Department of Molecular and Computational Biology
University of Southern California

Harry
--
Dr Harry Powell
Chairman of International Union of Crystallography Commission on Crystallographic Computing
Chairman of European Crystallographic Association SIG9 (Crystallographic Computing)