Hello,

I may have missed it but since I did not see a reply let me have a stab: I think there is no perfect way to do this, not least due to the fact that even an anatomically "correct" solution still assumes that the structure-function relationship is identical between your two diverse populations. But in any case, what you could do is to take the adult reference brain your spatial definitions are based on and warp it (non-linear only) to an appropriate pediatric reference brain. This warp could then be applied to the mask representing your activation, bringing it into a "pediatric" space.

Cheers
Marko

ARCHITH RAJAN wrote:

Dear Experts,

I have a well defined activation ROI from Adult population in the TT
space from a meta analysis(Ginger ALE).But the population I wish to
study are children.What would be the steps to transform the ROI from the
adult to children and also ensure that the location is the right one?


Regards,

Archith Rajan

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Prof. Dr. med. Marko Wilke
 Facharzt für Kinder- und Jugendmedizin
 Leiter, Experimentelle Pädiatrische Neurobildgebung
 Universitäts-Kinderklinik
 Abt. III (Neuropädiatrie)

Marko Wilke, MD, PhD
 Pediatrician
 Head, Experimental Pediatric Neuroimaging
 University Children's Hospital
 Dept. III (Pediatric Neurology)

Hoppe-Seyler-Str. 1
 D - 72076 Tübingen, Germany
 Tel. +49 7071 29-83416
 Fax  +49 7071 29-5473
 [log in to unmask]tuebingen.de

 http://www.medizin.uni-tuebingen.de/kinder/epn/
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