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Thank You,Sir for the reply. I also have one more question/problem I have used the TOM toolbox and have a children's template.But since the template is created from typically developing population and one of my groups is autistic,I would like to control for the effects of Total Intra Cranial Volume.But to estimate TIV I would need a template for segmentation,and a template with TIV as a covariate would be better suited to the population(I assume)-Which is kind of circular. Kindly comment on the same Regards Archith On Tue, Nov 15, 2016 at 9:48 PM, Marko Wilke < [log in to unmask]> wrote: > Hello, > > I may have missed it but since I did not see a reply let me have a stab: I > think there is no perfect way to do this, not least due to the fact that > even an anatomically "correct" solution still assumes that the > structure-function relationship is identical between your two diverse > populations. But in any case, what you could do is to take the adult > reference brain your spatial definitions are based on and warp it > (non-linear only) to an appropriate pediatric reference brain. This warp > could then be applied to the mask representing your activation, bringing it > into a "pediatric" space. > > Cheers > Marko > > > ARCHITH RAJAN wrote: > >> Dear Experts, >> >> I have a well defined activation ROI from Adult population in the TT >> space from a meta analysis(Ginger ALE).But the population I wish to >> study are children.What would be the steps to transform the ROI from the >> adult to children and also ensure that the location is the right one? >> >> >> Regards, >> >> Archith Rajan >> > > -- > ____________________________________________________ > Prof. Dr. med. Marko Wilke > Facharzt für Kinder- und Jugendmedizin > Leiter, Experimentelle Pädiatrische Neurobildgebung > Universitäts-Kinderklinik > Abt. III (Neuropädiatrie) > > Marko Wilke, MD, PhD > Pediatrician > Head, Experimental Pediatric Neuroimaging > University Children's Hospital > Dept. III (Pediatric Neurology) > > Hoppe-Seyler-Str. 1 > D - 72076 Tübingen, Germany > Tel. +49 7071 29-83416 > Fax +49 7071 29-5473 > [log in to unmask] > > http://www.medizin.uni-tuebingen.de/kinder/epn/ > ____________________________________________________ > >