Would this figure answer your question? Cells must have way of feeling the difference in the bond lengths, and strength and nuances in hybridization. At least, I hope they do.
From: CCP4 bulletin board [mailto:[log in to unmask]]
On Behalf Of Keller, Jacob
Sent: Thursday, November 10, 2016 3:42 PM
To: [log in to unmask]
Subject: [ccp4bb] Nitrate versus Carbonate
Dear Crystallographers,
I don’t think there is any feasible way crystallographically to distinguish between nitrate and carbonate or bicarbonate—correct? But that is not my main question.
My main question is: given that nitrate and carbonate are both very important and also very different physiologically, and therefore they must be distinguished/recognized by cells, how is this done, since the ions are so similar in structure?
Is there some aspect of these ions that differs dramatically of which I am not aware? What kind of “handles” could a protein grab onto to distinguish between nitrate and carbonate/bicarbonate?
JPK
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Jacob Pearson Keller, PhD
Research Scientist
HHMI Janelia Research Campus / Looger lab
Phone: (571)209-4000 x3159
Email:
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