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Just a gentle reminder that registration will close November 30, 2016. Giovanna ______________________________________________________________________________________________________________________________________________ On behalf of the School organizers, I would like to remind that registration for the International School of Crystallography 50th Course: Integrative Structural Biology, to be held in Erice (Italy) June 2-11, 2017, is now open. Please see below for details about the Course and how to apply. I hope to see many of you in Erice. Giovanna Scapin INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 50th Course: INTEGRATIVE STRUCTURAL BIOLOGY ERICE-SICILY: 2 - 11 JUNE 2017 E.Y. Jones and J.L. Martin (Directors of the Course) T.L. Blundell (Director of the School) WWW.CRYSTALERICE.ORG<http://WWW.CRYSTALERICE.ORG> Sponsored by the: * European Crystallographic Association * International Union of Crystallography * Italian Ministry of Education, University and Scientific Research * Sicilian Regional Government PURPOSE OF THE COURSE Over the last 50 years, crystallography has developed from a method capable of determining the structures of isolated, soluble proteins to one able to provide detailed information on mechanisms of action of integral membrane proteins, whole viruses and the complex nano-machines that are central to cellular function. To discover how biology works researchers are now combining the power of crystallography with multiple other methods, spanning from the atomic to cellular scale, and including revolutionary developments in electron cryo-microscopy and tomography. This Course will celebrate its milestone as the 50th in the crystallography series started by Dorothy Hodgkin by focusing on integration: 1) of different techniques, 2) of molecular and cellular approaches and 3) of the crystallographic community, including diversity. The aim is to provide young researchers with a review of the fundamental approaches and latest developments in the application of crystallography and hybrid methods to the structure and function of biological macromolecules and complexes. Lectures will exemplify use of integrated approaches to analyse molecular mechanism in human and pathogen biology. There will be hands-on workshops to provide practical experience and in-depth discussion of topics ranging from sample preparation to data analysis software. To commemorate the achievements of the Erice crystallography school over the past 50 years, the course will feature several sessions that reflect on the past and look to the future to highlight the factors that create an inclusive discipline. APPLICATIONS Interested candidates should register by 30th November 2016 using the form available in the school website (crystalerice.org<http://crystalerice.org/2017/welcome.php>). Applicants may be able to apply for partial financial support. Please visit crystalerice. org<http://crystalerice.org/2017/welcome.php> to view the full eligibility criteria. CURRENT LIST OF SPEAKERS AND TOPICS Nenad Ban (ETH Zurich): Protein synthesis by large cellular assemblies David Bardford(LMB Cambridge): The anaphase-promoting complex Pamela Bjorkman (Caltec): Immune recognition of viral pathogens Tom Blundell (Cambridge University): TBD and "Celebrating the 50th International School of Crystallography" Bridget Carragher (NYSBC): Intro to Cryo-EM Wah Chiu (Baylor College of Medicine) Electron cryo-microscopy of biological nanomachines Elena Conti (MPI for Biochemistry): RNA metabolism Piet Gros (Utrecht University): The complement system Sun Hur (Harvard University): Signal transduction by immune receptors Yvonne Jones (University of Oxford): Cell surface signaling assemblies Werner Kühlbrandt (MPI for Biophysics): Membrane proteins: Structure and mechanisms John Kuriyan, (UC Berkeley): Cellular signal transduction Debora Marks(Harvard University): TBD Jenny Martin (Griffith University): Antimicrobial drug design, Naoko Mizuno (MPI for Biochemistry): TBD Poul Nissen (Aarhus University): Membrane transporters in the brain, Lori Passmore (LMB Cambridge): TBD Michael Rossmann (Purdue University): The structure of the Zika virus Michael Rout (The Rockefeller University: The nuclear pore complex, Giovanna Scapin (Merck & Co): Structural Biology in Drug Discovery Irmi Sinning (Heidelberg University): Protein targeting and membrane protein biogenesis, Titia Sixma (NKI Amsterdam): Molecular mechanisms in carcinogenesis, David Stuart (University of Oxford): Virus structure and vaccine design, Sriram Subramaniam (NCI Bethesda): High resolution electron microscopy, Alessandro Vannini (ICR London): TBD Antoine van Oijnen (University of Wollongong): Single molecule biophysics, Wei Yang (NIDDK Bethesda): DNA repair, replication and recombination, Xiaodong Zhang (Imperial College London): DNA processing and damage response, WORKSHOPS Riccardo Pellarin (Pasteur Institute) Integrative Modeling Platform Cornelius Gati (MRC) RELION Randy Read (MRC) Validation/errors Paul Emsley (MRC) COOT Debbie Marks & Chris Sanders (Harvard) EV fold Airlie McCoy (MRC) Solution and refinement of large complexes/low resolution systems Ardan Patwardhan (EBI/PDBe) EMDB/EMPIAR: linking structural information from molecules to cells; Giovanna Scapin Principal Scientist Structural Chemistry Merck & Co., Inc. 2000 Galloping Hill Rd K15-1800 Room B133C Kenilworth NJ 07033 Phone +1 908 740 3632 Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth, New Jersey, USA 07033), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.