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This is not the only problem with this assay kit. Flyers in the normetanephrine peak convinced us not to introduce this assay and switch to LC-tandem MS. Best regards, Bart Ballieux B.E.P.B. Ballieux PhD, Clinical Biochemist Endocrinologist, Department KCL, E2-P. Leiden University Medical Centre, P.O.box 9600, 2300RC Leiden Tel: +3171-5262165/62278 Fax: +3171-5266753 email: [log in to unmask]<mailto:[log in to unmask]> P Please consider the environment before printing this e-mail Van: Clinical biochemistry discussion list [mailto:[log in to unmask]] Namens PERRY, Mandy (ROYAL DEVON AND EXETER NHS FOUNDATION TRUST) Verzonden: woensdag 30 november 2016 13:13 Aan: [log in to unmask] Onderwerp: Chromosystems urine metanephrine assay - (new) interefernec from capsaicin Dear Mailbase We have recently encountered an interesting problem with our Chromosystems urine metanephrine assay. We find that in some patient samples there is an interference present which runs at the same retention time as the internal standard. Chromsystems state that this is likely to be due to capsaicin from ingestion peppers. If this is the case then we are struggling to understand why this is a phenomenon that we have only seen recently. Chromsystems recommend that in these cases (which are recognised by an unusually large intervals standard peak) that we use an alternative internal standard with a retention time of ~17 minutes. Have any other Chromsystems users experienced this? Many thanks Mandy Mandy Perry, PhD FRCPath Clinical Scientist, Royal Devon and Exeter NHS Foundation Trust Blood Sciences, Template A2, Royal Devon and Exeter Hospital Barrack Road, Exeter, UK, EX2 5DW t: +44 (0)1392 402948 e: [log in to unmask]<mailto:[log in to unmask]> Website: www.exeterlaboratory.com<http://www.exeterlaboratory.com/> [cid:image003.png@01D1966B.04195090]<http://www.exeterlaboratory.com/> ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSi recipients NHSmail provides an email address for your career in the NHS and can be accessed anywhere For more information and to find out how you can switch, visit www.nhsdigital.nhs.uk/nhsmail<http://www.nhsdigital.nhs.uk/nhsmail> ******************************************************************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/