Hi Anderson,
Thanks for this model! To clarify the statistics underlying this model, is this performing a mixed effects model for the 2(between) x 3(within) interaction, or a repeated measures ANOVA?
I have a couple of questions regarding the implementation of this model in PALM, since I have not used PALM before. The design.ods you provided actually contains 2 separate files, and each of those files includes the design.mat and design.con for (a) the 2x3 interaction and (b) the main effect of group across all 3 conditions.
(1) I cannot find an example in PALM user information where one can enter 2 separate design.mats and design.cons into the same command. Are they supposed to be entered as separate files, or is there a way to combine the files in a way that will perform both models simultaneously?
(2) The EB column represents the exchangability blocks, within subjects. In the example provided, there should be a separate "blocks.csv" file input for the PALM command. [[palm -i modality1_4d.nii -d design.mat -t design.con -eb blocks.csv]] What is supposed to go into the blocks.csv file? If the EBs are already included within my design.mat file, do I also need a blocks.csv file?
(3) I have not added F-tests to a design.con file before (only in the GUI). Is this already in the appropriate format such that the F-test is indicated by the final column in the design.con file, and the rows with no F-test indicated are just empty?
(4) I would also like to include covariates of sex and Age (continuous). Can you advise how to modify this design to account for continuous covariates? Are they just added as separate EVs within the design.mat file?
(5) In addition, I would like to run a separate model to test the Age x Group x Emotion interaction. Is it possible to test a 3-way interaction with a continuous variable within this model framework in PALM?