Dear Mahmoud, I'm not sure about your version of eddy but I've used the 5.0.9. you are absolutely right. The .eddy_restricted_movement_rms was introduced as part of the 5.0.9 patch. Also, the function name is eddy_openmo not eddy. First make sure you have the latest patch for eddy. Then add --repol option and don't forget to use mutualinfo as cost function. I am not sure what you mean about the mutualinfo though. eddy has its own cost-function that is the sum-of-squared differences between the predicted and observed images. And you don’t need to specify that. Jesper Mahmoud On Fri, Oct 14, 2016 at 5:09 PM, Thais Minett <[log in to unmask]<mailto:[log in to unmask]>> wrote: Not really, My command was: eddy --imain=xxx_DTI.nii --mask=xxx_nodif_brain_mask.nii --index=index.txt --acqp=acqp.txt --bvecs=xxx_DTI.bvecs --bvals= xxx_DTI.bvals --fwhm=0 --flm=quadratic --out=xxx_data Regards, Thais Minett