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Hi, I'm running flirt from the command line calling previously defined registration .mat files. However, the output file is very large (over 200 mb) per subject when the original file is only 40 mb. Can someone please explain why this is happening and how to correct it (if possible). This is registering fmri (4D) data to MNI space. flirt -in input.nii.gz -ref subject.feat/reg/standard.nii.gz -out subjectMNI -init subject.feat/reg/example_func2standard.mat -applyxfm Cheers, Will