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Dear SPM Experts I understand that DARTEL currently only works with images that have isotropic voxels (p. 184 manual). I am wondering whether it is possible/advisable to use DARTEL with non-isotropic images using some kind of workaround - eg. resampling or reslicing the images to be isotropic in an a prior spatial preprocessing step (e.g. from 3x3x2 to 2x2x2). Specifically, my EPI images have been collected in 3x3x2mm voxels using a multiband technique. I appreciate that this may be a very basic question, and probably exposes my SPM inexperience. Many thanks *Dr Matthew Nour* Clinical Research Fellow Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience King's College London London, UK