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Can't one always assume a healthy dose of irony with all ".uk" email addresses? JPK -----Original Message----- From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Randy Read Sent: Wednesday, July 06, 2016 9:36 AM To: [log in to unmask] Subject: Re: [ccp4bb] How to answer a reviewer Dear Kay, Thanks for clarifying that! Indeed, I should have used a different word or put "rewarded" in quotation marks to make the ironic intent clearer! Randy > On 6 Jul 2016, at 14:05, Kay Diederichs <[log in to unmask]> wrote: > > On Wed, 6 Jul 2016 09:13:22 +0100, Randy Read <[log in to unmask]> wrote: > >> Dear Zbyszek, >> >> I agree completely with your general point that there is a trend for an increasing number of people to adopt too-low symmetry, rewarded by lower R-factors in twinned refinement. > > Dear Randy, > > I wish you had not used the word "rewarded" - for Germans at least, it has no ironic or pejorative connotation. I hope people do not understand this as if you were endorsing this unfortunate practice. There are already too many structures being twin-refined "because it reduces the R-factors" (and I fell into this trap as well before reading Garib N. Murshudov (2011) "Some properties of crystallographic reliability index - Rfactor: effect of twinning" Appl. Comput. Math., V.10, N.2, 2011, pp.250-261 http://www.ysbl.york.ac.uk/refmac/papers/Rfactor.pdf ). > > best, > > Kay > > > ------ Randy J. Read Department of Haematology, University of Cambridge Cambridge Institute for Medical Research Tel: + 44 1223 336500 Wellcome Trust/MRC Building Fax: + 44 1223 336827 Hills Road E-mail: [log in to unmask] Cambridge CB2 0XY, U.K. www-structmed.cimr.cam.ac.uk