It is potentially possible, but the low resolution tends to present challenges and I don’t have much experience with animal ASL registration. You will probably find that the more you can get a good initial alignment, e.g. manually getting the low and high res images aligned, the better any automated registration (restricted to a narrow search range) should work.

Michael

> On 22 Jun 2016, at 19:49, SUBSCRIBE FSL Anonymous <[log in to unmask]> wrote:
>
> Dear FSL experts,
>
> We have few animal ASL data. According to guideline, we have got ASL-perfusion map, however, its resolution was very low.
>
> I am wondering if I can registration ASl-perfusion map into higher resolution structural images?
>
> Thanks
> Shiyao