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Hi, I'm afraid that this sounds like a problem with the version packaged for neurodebian, so you might need to contact the neurodebian mailing list to see if they can help. However, it might be a problem related to the LD_LIBRARY_PATH and DYLD_LIBRARY_PATH variables. It would be helpful to know what these are normally set to. There is a line in possumX that might be causing a problem on the neurodebian systems. This line is (in our code on other systems): unset LD_LIBRARY_PATH DYLD_LIBRARY_PATH DYLD_FALLBACK_LIBRARY_PATH So it might be the case that commenting this line out (or uncommenting if it is different in the neurodebian version) could help. Let us know how you get on. All the best, Mark From: FSL - FMRIB's Software Library <[log in to unmask]<mailto:[log in to unmask]>> on behalf of Gengyan Zhao <[log in to unmask]<mailto:[log in to unmask]>> Reply-To: FSL - FMRIB's Software Library <[log in to unmask]<mailto:[log in to unmask]>> Date: Wednesday, 29 June 2016 at 00:01 To: "[log in to unmask]<mailto:[log in to unmask]>" <[log in to unmask]<mailto:[log in to unmask]>> Subject: [FSL] a problem with possum Hello FSL Masters, I have encountered a problem with possum. I installed the fsl-5.0-complete on my ubuntu 14.04 system according to the instruction on the neuro.debian website, and then I added a line ". /etc/fsl/5.0/fsl.sh" to the end of my .profile file. Loged out and loged in. I could run other parts of the fsl, but when I ran possum. The file ~/simdir/logs/possum.e13545.1 will report: /usr/share/fsl/5.0/bin/possum: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory and the file ~/simdir/logs/possumX_postproc.sh.e13598 will report: fslmaths: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory fslstats: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory fslstats: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory (standard_in) 1: syntax error fslmaths: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory fslstats: error while loading shared libraries: libnewimage.so: cannot open shared object file: No such file or directory /usr/share/fsl/5.0/bin/fslhd: error while loading shared libraries: libfslio.so: cannot open shared object file: No such file or directory Thank you in advance. Best, Gengyan